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Methotrexate CAS 59-05-2 (jerryzhang001@chembj.com)

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  Post Date: Apr 20,2017
  Expiry Date: Apr 20,2018
  Detailed Description: Cas No. :59-05-2 Payment Method: T/T; Western Union; Moneygram and Bitcoin
Methotrexate CAS 59-05-2

Product Name: Methotrexate;
Synonyms: METHOTREXATE;METHYLAMINOPTERIN;METHYLAMINOPTERINE;ANTIFOLAN;L-(+)-AMETHOPTERIN;4-AMINO-N 10-METHYLPTEROYL-L-GLUTAMIC ACID;4-AMINO-10-METHYLPTEROYLGLUTAMIC ACID;(+)-4-AMINO-10-METHYLFOLIC ACID;
CAS: 59-05-2;
MF: C20H22N8O5;
MW: 454.44;
EINECS: 200-413-8;

Product Categories: Aromatic Esters;Antibiotics for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;API's;Antitumour;Aromatics;Bases & Related Reagents;Chiral Reagents;Heterocycles;Nucleotides;Inhibitor;API;Anti-cancer&immunity;Inhibitors;

Melting point: 195°C;
storage temp.: −20°C;


Description:

Methotrexate is a drug used for the treatment of cancer, also known as cytotoxic drugs. In order to reduce its cytotoxicity, it can be used in conjunction with calcium leucovorin. It is primarily used for the treatment of acute leukemia (acute lymphocytic leukemia), breast cancer, malignant mole and choriocarcinoma, head and neck cancer, bone cancer, leukemia, spinal cord meningeal infiltration, lung cancer, reproductive system cancer, liver cancer, refractory psoriasis vulgaris, dermatomyositis, body myositis, ankylosing spondylitis inflammation, Crohn's disease, psoriasis and psoriatic arthritis, Behcet's disease and autoimmune disease.

Methotrexate is an immunosuppressant and can be used for easing the process of rheumatism with a particularly excellent efficacy in treating synovial inflammation of rheumatoid arthritis and is the most frequently used drugs for treating rheumatoid diseases.

The main side effects of methotrexate include: nausea, vomiting and diarrhea, liver damage, mouth ulcers, pneumonia, sepsis, and Nocardia, mild fatigue and headaches, dry skin.

Clinical application:

It is effective in treating acute leukemia with better efficacy in pediatric patients. It has a good efficacy in treating choriocarcinoma and malignant mole. Large dose administration is effective in treating osteosarcoma, soft tissue sarcoma, lung cancer, testicular cancer, breast cancer, and ovarian cancer.

It is also effective in treating head and neck cancer, liver cancer and gastrointestinal cancer. Arterial infusion of this product has goo efficacy in treating head and neck cancer and liver cancer. However, it is rarely used for treating psoriasis and psoriasis.

  CAS Registry Number:

59-05-2

  Synonyms: ;Methylaminopterin;Methylaminopterine;Antifolan;L-(+)-Amethopterin;(+)-Amethopterin;Amethopterin;4-Amino-N 10-Methylpteroyl-L-Glutamic Acid;4-Amino-1;Methylpteroylglutamic Acid;(+)-4-Amino-10-Methylfolic Acid;4-Amino-10-Methylfolic Acid;N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid;N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid;Mtx;4-Amino-4-Deoxy-N(Sup10;Methylpteroylglutamate;4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid;
  Molecular Formula: C20H22N8O5
  Molecular Weight: 454.44
  Molecular Structure: 59-05-2 Methotrexate
  Hazard Symbols:  T:Toxic;
  Risk Codes: R61:;
R25:;
R36/38:;
  Safety Description: S53:;
S26:;
S36/37:;
S45:;

  Company: Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        
  Contact: Jerry Zhang
  Tel: 86-25-52198306
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  Email: jerryzhang001@chembj.com
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