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Flagentyl
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| Post Date: | Aug 12,2014 |
| Expiry Date: | Feb 08,2015 |
| Detailed Description: |
Cas No. :3366-95-8
Quantity: 10Kilograms Specs:Secnidazole,Flagentyl,3366-95-8 Price:1-10000 USD Kilograms Payment Method: T/T,L/C.WU Product Name： Secnidazole Other names: Flagentyl, Sindose, Secnil Category: pharmaceutical raw material bulk drugs api CAS NO: 3366-95-8 M.F.: C7H11N3O3.1/2H20 Quality standard: YBH12562008; Edition: CP Applicable category:Antianaerobic-microbacterial drug,antitrichomonal agent ; Finished dosage: Secnidazole capsules, Secnidazole tablets ; Appearance: almost white to pale yellow crystalline powder,odourless,bitter flavor; Freely soluble in ethanol, chloroform and propanol,sparingly soluble in 0.1mol/l hydrochloric acid, slightly soluble in water; Assay: not less than 99% on anhydrous basis; Loss on drying: 4.5 %~6% Appearance of solution: clear and colorless; Melting point: 74~78℃; Related impurities:The peak area of total impurities ≤1%; Heavy metal: ≤10 ppm; Packing: 10 kg/drum Advantage: High purity, Low heavy metal, Low related impurities, GMP certificate, Profession Activity & Sevice: pharmaceuticals looking for distributors, wholesale pharmaceutical generic drugs, provide lab testing service pharmaceutical Product Introduction: Secnidazole is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.It has also been tested against Atopobium vaginae. Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. In patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2 g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole. Patients with hepatic amoebiasis appears to respond well to 5- to 7-day therapy with secnidazole, but the efficacy of this drug regimen requires further evaluation in larger numbers of patients. After administration of a single dose of secnidazole, parasitological eradication was achieved in approximately 92 to 100% of patients with urogenital trichomoniasis. Patients with bacteria vaginosis respond at least as well to a single dose of secnidazole as to single-dose tinidazole, or single- or 7-day treatment with metronidazole; clinical improvement and/or microbiological evidence of cure was attained in approximately 59 to 96% of patients. In the clinical trials reviewed, secnidazole was well tolerated; most adverse events were gastrointestinal in nature and did not require treatment intervention or withdrawal from therapy. In summary, available evidence suggests that secnidazole is as efficacious as other 5-nitroimidazole drugs in the treatment of protozoal infections and bacterial vaginosis. The convenience and ease of administration associated with single-dose therapy, combined with a good tolerability profile, make secnidazole a suitable option to other single-dose treatments and an attractive alternative to multiple dosage regimens with other drugs in this class. |
| CAS Registry Number: | 3366-95-8 |
| Synonyms: | ;alpha,2-dimethyl-5-nitro-1h-imidazole-1-ethanol;1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol; |
| Molecular Formula: | C7H11N3O3 |
| Molecular Weight: | 185.1805 |
| Molecular Structure: | 
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| Company: | Hunan Dinuo Pharmaceuical Co.,Ltd [ China ] |
| Contact: | WIlliam Wang |
| Tel: | +86-0731-88280100-8561/2 |
| Fax: | +86-0731-88280157 |
| Email: | sales@cphi-dinuo.com |
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