Indole-3-Carbinol
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| Post Date: | Jan 03,2013 |
| Expiry Date: | Jan 03,2014 |
| Detailed Description: |
Cas No. :700-06-1
Phytochemical:Indole-3-Carbinol
Synonyms:I3C, 3-hydroxymethyl indole, 3-indole methanol Specification:99%(HPLC) Appearance: white powder CAS:700-06-1 Function: Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures. Chemopreventive Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins. Anticancer The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer. Heart health A few studies demonstrate the beneficial effects of indole-3-carbinol on lipid synthesis and platelet aggregation, suggesting that this phytochemical could help to improve heart health. |
| CAS Registry Number: | 700-06-1 |
| Synonyms: | ;Indolemethanol;3-(Hydroxymethyl)indole;3-Indolemethanol;1H-Indol-3-ylmethanol;Indole-3-methanol;1H-Indole-3-methanol;I3C;AKOS NCG1-0099;3-Indole methanol;Indo-3-Carbinol; |
| Molecular Formula: | C9H9NO |
| Molecular Weight: | 147.18 |
| Molecular Structure: | 
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| Hazard Symbols: |  Xi:Irritant; |
| Risk Codes: | R36/38:; |
| Safety Description: | S26:; S36:; |
| Company: | xi'an chukang biotechnology [ China ] |
| Contact: | johnson zhang |
| Tel: | 029-63685358 |
| Fax: | 029-62698968 |
| Email: | huike8@126.com |
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