| Nom |
Gemtuzumab Ozogamicin |
| Synonymes |
Gemtuzumab ozogamicin [USAN]; CDP 771; CMA 676; Gemtuzumab; Gemtuzumab ozogamicin; Immunoglobulin G4 (human-mouse monoclonal hP67.6 gamma4-chain anti-human antigen CD33), disulfide with human-mouse monoclonal hP67.6 kappa-chain, dimer, conjugate with methyl (1R, 4Z, 8S, 13E)-13-(2-((2-(((p-(3-carbamoylpropoxy)-alpha-methylbenzylidene)hydrazino)carbonyl)-1,1-dimethylethyl)dithio)ethylidene)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-o-toluoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-O-(2,4-dideoxy-4-(N-ethylacetamido)-3-O-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyne-10-carbamate. Molecular weight is approximately 153,000 daltons; Immunoglobulin G4, anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 gamma4-chain), disulfide with human-mouse monoclonal hP67.6 kappa-chain, dimer, methyl ((1R,4Z, 8S, 13E)-(8-((2-O-(4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-alpha-L-threo-pentopyranosyl)-4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-13-(2-((3-((1-(4-(4-amino-4-oxobutoxy)phenyl)ethylidene)hydrazino)-1,1-dimethyl-3-oxopropyl)dithio)ethylidene)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate conjugate; Mylotarg; UNII-8GZG754X6M; WAY-CMA 676; Immunoglobulin G4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 gamma4-chain)), disulfide with human-mouse monoclonal hP67 6kappa-chain, dimer, methyl ((1R,4Z,8S,13E)-8-((2-O-(4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-alpha-L-threo-pentopyranosyl)-4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-13-(2-((3-((1-(4-(4-amino-4-oxobutoxy)phenyl)ethylidene)hydrazino)-1,1-dimethyl-3-oxopropyl)dithio)ethylidene)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate conjugate; 5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-N~5~-(diaminomethylidene)ornithyl-N-ethylprolinamide |
| Formule moléculaire |
C59H84N16O12 |
| Poids Moléculaire |
1209.3983 |
| InChI |
InChI=1/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64) |
| Numéro de registre CAS |
220578-59-6 |
| Structure moléculaire |
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| Densité |
1.44g/cm3 |
| Indice de réfraction |
1.681 |
| Les symboles de danger |
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| Codes des risques |
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| Description de sécurité |
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