Phenacetin
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| Post Date: | Nov 18,2017 |
| Expiry Date: | May 17,2018 |
| Detailed Description: |
Cas No. :62-44-2
Quantity: mass in stockKilograms Specs:white powder Price:negotiable USD Kilograms Payment Method: T/T, Western Union,Moneygram and Bitcoin. Description: Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin. Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities. Applications: Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity. Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research. How It Works: Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia. It is metabolised in the body as paracetamol (acetaminophen). Dosage: Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4-6 times per day, and the daily dose was not to exceed 2 g. |
| CAS Registry Number: | 62-44-2 |
| Synonyms: | ;1-acetamido-4-ethoxybenzene;para-Acetophenetidide;p-acetophenetidine;p-acetophenetide;p-acetphenetidin;paracetophentidin;p-Ethoxyacetanilide;4'-ethoxyacetanilide;Para-phenacetin;acet-p-phenalide;acet-p-phenetidin;aceto-para-phenalide;aceto-para-phenetidide;Acetophenetidine;acetophenetin;acetylphenetidin;coricidin;empirin compound;N-(4-ethoxyphenyl)-acetamide;N-Acetyl-4-ethoxyaniline;N-acetyl-p-phenetidine;phenacet;phenacitin;phenazetin;Phorazetim;pyraphen; |
| Molecular Formula: | C10H13NO2 |
| Molecular Weight: | 179.2157 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; |
| Risk Codes: | R22:; R45:; |
| Safety Description: | S45:; S53:; |
| Company: | Hengyang Desen Science and Technology co., LTD. [ China ] |
| Contact: | Eric yang |
| Tel: | +86-189-08446905 |
| Fax: | |
| Email: | Eric@desen-nutrition.com |
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