Vinpocetine CAS 42971-09-5 (jerryzhang001@chembj.com)

• Post Date:

  Apr 20,2017

• Expiry Date:

  Apr 20,2018

• Detailed Description:

  Cas No. :42971-09-5 Payment Method: T/T; Western Union; Moneygram and Bitcoin
  Vinpocetine CAS 42971-09-5
  
  
  Product Name: Vinpocetine
  Synonyms: 3A,16A-APOVINCAMINIC ACID ETHYL ESTER;(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;VINPOCETIN;
  
  CAS: 42971-09-5;
  MF: C22H26N2O2;
  MW: 350.45;
  EINECS: 256-028-0;
  
  Product Categories: Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Chiral Reagents;Heterocycles;ACTONEL;Cardiovascular APIs;
  
  
  Melting point: 147-153 °C dec.;
  storage temp.: Store at RT;
  
  Description:
  
  Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism. Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc.
  
  It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
  Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively. Pharmacological effects are as follows:
  
  ①Inhibit the activity of calcium dependency phosphodiesterase, increase the content of cAMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow.
  ②Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation.
  ③Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism.
  ④Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, inhibit the generation of lipid peroxide in the brain, delay the occurring of spasm caused by cerebral ischemia, have the function of improving cerebral metabolism and protecting brain.
  
  Medicinal properties and Application:
  
  Vinpocetine is also called Ethyl apovincaminate, Conway, Karan and Vinpocetine. It is a kind of natural medicine extracted from small vinca flower, and belongs to the indole alkaloids. Can be synthetic now.
  
  The mechanism of its pharmacological action is to inhibit the activity of calcium dependency phosphodiesterase, increase the content of CGMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow; Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation; Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism; Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, increase thedegree of oxygen dissociation in hemoglobin;
  
  Increase the resistance capacity for cerebral anoxia and occurring of spasm caused by cerebral ischemia, inhibit the generation of lipid peroxide in the brain. Oral absorption effectively, reach peak at 1 h, then metabolize into Vinpocetine in the body. The half-life of plasma elimination is about 1 hour. For 4 weeks in a row, no accumulation in the body. Clinical used in cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, cerebral vasospasm, brain endarteritis caused vertigo, tinnitus, headache, dizziness, limb numbness, incontinence and other clinical manifestations, depression, anxiety, sleep disorder and other mental symptoms. Clinical experience has shown that it is effective regardless of the length of the course of the disease, and the symptom is fixed or not.
  
  Usage:
  
  Cerebrovascular drug. A alkaloid extracted from apocynaceae plant, Vincamine derivatives. Selectively inhibit vascular smooth muscle calcium dependency phosphodiesterase, and increase the content of cGMP, expanse cerebral vascular, which in turn increase cerebral blood flow, improve cerebral circulation, but has little effects on the cardiovascular and blood pressure.
  
  Effectively, good tolerance, less adverse reaction. Used for dizziness, headache, memory disorders, movement disorder, aphasia, hypertensive encephalopathy, etc.. Can also be used in brain blood circulation obstacle caused by mental or neurological symptoms.

• CAS Registry Number:

  42971-09-5

• Synonyms:

  ;(+)-Apovincaminic acid ethyl ester;(+)-cis-Apovincaminic acid ethyl ester;3-alpha,16-alpha-Apovincaminic acid ethyl ester;AY 27,255;Apovincaminate d'ethyle;Apovincaminate d'ethyle [French];Apovincaminic acid ethyl ester;BRN 0900803;Cavinton;Ethyl (+)-apovincaminate;Ethyl (+)-cis-apovincaminate;Ethyl apovincamin-22-oate;RGH 4405;RGH-4405;TCV-3B;UNII-543512OBTC;Vinpocetinum;Vinpocetinum [INN-Latin];cis-Apovincaminic acid ethyl ester;Eburnamenine-14-carboxylic acid, ethyl ester, (3-alpha,16-alpha)-;Eburnamenine-14-carboxylic acid, ethyl ester, (3alpha,16alpha)-;ethyl eburnamenine-14-carboxylate;ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate;(3alpha,16alpha)-14-(ethoxycarbonyl)eburnamenin-4-ium;

• Molecular Formula:

  C₂₂H₂₇N₂O₂

• Molecular Weight:

  351.4614

• Molecular Structure:

  

• Hazard Symbols:

   Xn:Harmful;
  

• Risk Codes:

  R22:;
  

• Safety Description:

  S36:;
  

• Company:

  Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        

• Contact:

  Jerry Zhang

• Tel:

  86-25-52198306

• Fax:

• Email:

  jerryzhang001@chembj.com