Andrographis extract Series

• Post Date:

  Nov 26,2013

• Expiry Date:

  Nov 26,2014

• Detailed Description:

  Cas No. :5508-58-7 Specs:above 99%
  Andrographis extract Series
  
  Plant origin: extract from whole herb and leaf of Acanthaceae plant Andrographis (Andrographis paniculata (Burm.f.) Nees)
  
  Chemical ingredient: andrographolide, neoandrographolide, 14-deoxy andrographolide, andrographoside, 14-deoxyaandrographoside, Dehydroandrographolide lactones and flavonoids.
  
  Specifications: Andrographis extract ( total lactone content from 5 to 30% ); andrographolide content ≥ 99%; dehydroandrographolide; Neoandrographolide.
  
  Andrographis extract
  
  Name: Andrographis dry extract, Andrographolide
  
  Characters: Andrographis extract is dark green or brown ( after bleaching ) powder or lumps, odorless, very bitter taste.
  
  Content: Dry extract contains paniculta lactone, dehydration paniculta lactone is 5 ~ 30%
  
  Method: HPLC method ( refer to Chinese Pharmacopoeia 2010 edition )
  
  Standard: Corporate standard
  
  Andrographolide
  
  Molecular formula:C20H30O5
  
  Molecular Weight: 350.44
  
  CAS number:5508-58-7
  
  Properties: white square prismatic or crystals flakes ( ethanol or methanol ), odorless, bitter taste. Dissolved in boiling ethanol,slightly soluble in methanol or ethanol, very slightly soluble in chloroform, almost insoluble in water and ethyl ether
  
  Melting point 230 - 231 centigrade degree
  
  Content: above 99%
  
  Method: HPLC method
  
  Dehydroandrographolide
  
  Molecular formula: C20H28O4
  
  Molecular Weight: 332.42
  
  Properties: Colorless crystalline needle ( 30% or 50 % ethanol ), freely soluble in ethanol, acetone, soluble in chloroform, slightly soluble in benzene, almost insoluble in water. Melting point 204 centigrade degree.
  
  Content: above 99%
  
  Method: HPLC method
  
  Neoandrographolide
  
  Chemical name:19-hydroxy-8 (17) ,13-laboiadien-16,15-olide-o-βD-glucopyranoside
  
  CAS number: 27215-14-1
  
  Molecular formula: C26H40O8
  
  Molecular Weight: 480.58
  
  Properties:colorless columnar crystals, no bitterness. Soluble in methanol, ethanol, acetone and pyridine, slightly soluble in chloroform and water, insoluble in ethyl ether and petroleum ether.
  
  Melting point 167 - 168 centigrade degree, boiling point 668.1 centigrade degree, the refractive index of 1.576 , flash point 220.1 centigrade degree, density: 1.27g/cm3, optical rotation [α] D-48 degree ( pyridine ), -45 degree (c = 1, ethanol ).
  
  Content:above 98%
  
  Method: HPLC method
  
  Pharmacology efficacy: Neoandrographolide has function of heat-clearing and detoxifying, relieve swelling and pain. Animal experiments show that it inhibit and delay fever effect caused by the pneumococcus and hemolytic streptococcus. Also has inhibition cough and asthma. Suitable for the treatment of acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, faucitis, and so on.
  
  

• CAS Registry Number:

  5508-58-7

• Synonyms:

  ;NSC 383468;UNII-410105JHGR;2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-;3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one;4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one;(2R,5S,6S,10R,12E,14S)-2,14,17-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal;(5S,10R,12E)-2,14,16-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal;(2R,5S,10R,12E,14S)-2,14,17-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal;andrographolide,14-deoxy 11,12-didehydro;

• Molecular Formula:

  C₂₀H₃₀O₅

• Molecular Weight:

  350.4492

• Molecular Structure:

  

• Safety Description:

  S22:;
  S24/25:;
  

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