China Epoxomicin API High purity

• Post Date:

  Oct 26,2015

• Expiry Date:

  Apr 23,2016

• Detailed Description:

  Cas No. :134381-21-8 Quantity: 1000g
  Specs:90%
  Price:1 USD Kilograms
  Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
  in vitro: Epoxomicin inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM . By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM.
  in vivo: Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson’s-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons.

• CAS Registry Number:

  134381-21-8

• Synonyms:

  ;BU-4061T;EPOXOMICIN, SYNTHETIC;(2R)-2-[ACETYL-(N-METHYL-L-ISOLEUCYL)-L-ISOLEUCYL-L-THREONYL-L-LEUCYL]-2-METHYLOXIRANE;n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide;N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl}-L-leucinamide;N-acetyl-N-methyl-L-isoleucyl-N-{(2S,3R)-3-hydroxy-2-[(3-methyl-1-{[(2R)-2-methyloxiran-2-yl]carbonyl}butyl)amino]butanoyl}-L-isoleucinamide;

• Molecular Formula:

  C₂₈H₅₀N₄O₇

• Molecular Weight:

  554.7192

• Molecular Structure:

  

• Company:

  BSAZ(HANGZHOU)BIOTECH CO.LTD.     [ China ]        

• Contact:

  Sales Manager

• Tel:

  +86-571-28257297

• Fax:

  +86-571-56260350

• Email:

  order@bsaz.net