Dutasteride 164656-23-9

• Post Date:

  Jan 15,2019

• Expiry Date:

  Jan 15,2020

• Detailed Description:

  Cas No. :164656-23-9 Dutasteride (CAS 164656-23-9)
  
  Synonym: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Avolve; GG 745; GI 198745; Veltride
  Application: A dual inhibitor of 5α-reductase isoenzymes type 1 and 2
  CAS Number: 164656-23-9
  Purity: ≥99%
  Molecular Weight: 528.53
  Molecular Formula: C27H30F6N2O2
  
  Description
  Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.
  Technical Information
  Appearance: Crystalline powder
  Physical State: Solid
  Solubility: Soluble in ethanol (44 mg/ml), methanol (64 mg/ml), polyethylene glycol 400 (3 mg/ml), and DMSO (62 mg/ml at 25 °C 117mM). Insoluble in water.
  Storage: Store at 4° C
  Melting Point: 247-248 °C
  Boiling Point: ~620.3 °C at 760 mmHg (Predicted)
  Density: ~1.3 g/cm3 (Predicted)
  Refractive Index: n20D 1.52 (Predicted)
  IC50: 3 β-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase: IC50 >0.15 mM (Mycobacterium tuberculosis)
  pK Values: pKa: 13.32 (Predicted)
  Safety and Reference Information
  PubChem CID: 6918296
  MDL Number: MFCD00937869
  Beilstein Registry: 7401530
  SMILES: C[C@]12CC[C@H]3[C@@H](CC[C@H]4NC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)NC1=CC(= CC=C1C(F)(F)F)C(F)(F)F

• CAS Registry Number:

  164656-23-9

• Synonyms:

  ;(5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;(4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;(4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;

• Molecular Formula:

  C₂₇H₃₀F₆N₂O₂

• Molecular Weight:

  528.5297

• Molecular Structure:

  

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  Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd     [ China ]          

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