Human ABL1 peptide

• Post Date:

  Apr 07,2017

• Expiry Date:

  Apr 07,2018

• Detailed Description:

  The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008] http://www.creative-diagnostics.com/c-Abl-peptide-176441-427.htm
  

• Company:

  Creative Diagnostics     [ United States ]        

• Contact:

  Emily Dean

• Tel:

  1-631-619-7922

• Fax:

• Email:

  contact@creative-diagnostics.com