Liothyronine sodium

• Post Date:

  Jul 04,2016

• Expiry Date:

  Jul 04,2017

• Detailed Description:

  Cas No. :55-06-1
  
  High Purity Liothyronine Methenolone Enanthate Sodium Treat Hypothyroidism
  
  
  Quick Detail:
  
  
  
  Liothyronine is a form of thyroid hormone used to treat hypothyroidism and myxedema coma. It is marketed as the sodium salt under the brand name Cytomel (or Tertroxin in Australia).
  
  
  
  Description:
  
  
  
  Liothyronine sodium
  
  Alias: Cytomel T3 ; 3,3',5－triiodothyronine sodium
  CAS NO:55-06-1
  Einecs No: 200-223-5
  MF: C15H11I3NNaO4
  MW: 672.96
  Purity: 98.0%
  Appearance: white or light yellow powder, almost tasteless.
  
  
  
  
  Applications:
  
  
  
  
  
  High Purity Liothyronine sodium/Cytomel T3/3,3',5－triiodothyronine sodium/CAS No: 55-06-1 200-223-5 Weight Loss Powders
  
  Liothyronine is the most potent form of thyroid hormone. Chemically, it is nearly identical to triiodothyronine (T3). As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
  
  In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
  
  Physicians can use this instead of or in addition to levothyroxine (T4) for patients undergoing thyroid withdrawal. When a patient has thyroid cancer or Graves' disease, ablation therapy with radioactive iodine can be used to remove any trace thyroid tissue. For 131I therapy to be effective, the trace thyroid tissue must be avid to iodine. The best method is to starve the tissue of iodine but this can lead to hypothyroid symptoms for the patient. Withdrawal from levothyroxine can be done but it takes six weeks of withdrawal for the remaining thyroid tissue to be completely starved. Six weeks is needed owing to levothyroxine's long half life. Six weeks can be inconvenient for the patient and delay treatment. Liothyronine instead can be taken and withdrawn from for two weeks to starve the thyroid tissue. This is much safer and more convenient than levothyroxine.
  
  
  
  
  
  Specifications:
  
  
  
  
  
  Item
  Specification
  Result
  
  Appearance
  An odorless, almost white or buff colored powder
  pass
  
  Solubility
  1,Very slightly soluble in water
  pass
  
  2,slightly soluble in alcohol
  pass
  
  3,practically insoluble in most other organic solvents
  pass
  
  4,disolves in diluted aqueous sodium hydroxide solutions
  Pass
  
  Identificaton
  a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved.
  pass
  
  b)The retention time of the major peak is confirm to the RS
  pass
  
  Loss on Drying
  Not more than 4.0%
  0.46%
  
  [a]20/D
  
  C=1 in1MHCl/EtOH 1:4
  +18 ~ +22o
  ＋20.9o
  
  Assay(HPLC)
  Not less than 95.0%
  99.18%
  
  Levothyroxine sodium
  Not more than 5.0%
  0.68%
  
  Conclusion:
  Up to the Standard for Export
  
  
  
  
  
  
  
  
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• CAS Registry Number:

  55-06-1

• Synonyms:

  ;Liothyronine Sodium;3,3,5-Triiodo-L-thyronine.Na;T3;sodium L－triiodothyronine;(S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT;SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE;T3 SODIUM SALT;T3, NA;O-[4-HYDROXY-3-IODOPHENYL]-3,5-DIIODO-L-TYROSINE SODIUM SALT;LIOTHYRONINE SODIUM SALT;H-THY(3,3',5-I3)-ONA;sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate;sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate hydrate;3,3',5-Triiodo-L-thyronine sodium salt(T3);

• Molecular Formula:

  C₁₅H₁₃I₃NNaO₅

• Molecular Weight:

  690.9706

• Molecular Structure:

  

• Safety Description:

  S24/25:;
  

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  Wuhan Yuancheng Gongchuang Technology Co     [ China ]        

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