Loperamide hydrochloride

• Post Date:

  Jan 09,2018

• Expiry Date:

  Jul 08,2018

• Detailed Description:

  Cas No. :34552-83-5 Quantity: mass in stockKilograms
  Specs:white powder
  Price:negotiable USD Kilograms
  Payment Method: T/T, Western Union,Moneygram and Bitcoin.
  Description:
  
  Loperamide, sold under the brand name Imodium among others, is a medication used to decrease the frequency of diarrhea.It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome. It is not recommended for those with blood in the stool.The medication is taken by mouth.
  
  Common side effects include abdominal pain, constipation, sleepiness, vomiting, and a dry mouth.It may increase the risk of toxic megacolon.Loperamide's safety in pregnancy is unclear, but there is no evidence of harm. It appears to be safe in breastfeeding. It is an opioid with no significant absorption from the gut and does not cross the blood brain barrier when used at normal doses. It works by slowing the contractions of the intestines.
  
  Loperamide was first made in 1969 and used medically in 1976.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.Loperamide is available as an inexpensive generic medication.
  
  Medical uses
  Loperamide is effective for the treatment of a number of types of diarrhea. This includes control of acute nonspecific diarrhea, mild traveler's diarrhea, irritable bowel syndrome, chronic diarrhea due to bowel resection, and chronic diarrhea secondary to inflammatory bowel disease. It is also useful for reducing ileostomy output. Off-label uses for loperamide also include chemotherapy induced diarrhea, especially related to irinotecan use.
  
  Loperamide should not be used as the primary treatment in cases of bloody diarrhea, acute exacerbation of ulcerative colitis, or bacterial enterocolitis.
  
  Loperamide is often compared to diphenoxylate. Recent studies suggest that loperamide is more effective and has lower neural side effects.
  
  Side effects
  Adverse drug reactions (ADRs) most commonly associated with loperamide are constipation (which occurs in 1.7–5.3% of users), dizziness (up to 1.4%), nausea (0.7–3.2%), and abdominal cramps (0.5–3.0%).Rare, but more serious, side-effects include: toxic megacolon, paralytic ileus, angioedema, anaphylaxis/allergic reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, urinary retention, and heat stroke.The most frequent symptoms of loperamide overdose are drowsiness, vomiting and abdominal pain or burning.
  
  High doses may result in heart problems such as abnormal heart rhythms.

• CAS Registry Number:

  34552-83-5

• Synonyms:

  ;4-(4-(p-Chlorophenyl)-4-hydroxy-1-piperidyl)-N,N-dimethyl-2,2-diphenylbutyramide HCl;4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide HCl;4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide monohydrochloride;BLOX;BREK;Dissenten;Fortasec;Imodium;Imodium A-D;Imodium A-D EZ chews;Imosec;Lopemid;Lopemin;Loperamide HCl;Loperyl;Maalox Antidiarrheal;PJ185;R 18553;Suprasec;Tebloc;UNII-77TI35393C;Up and up anti diarrheal;1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, hydrochloride;1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, monohydrochloride;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenylpiperidine-1-butyramide monohydrochloride;4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride (1:1);

• Molecular Formula:

  C₂₉H₃₄Cl₂N₂O₂

• Molecular Weight:

  513.4985

• Molecular Structure:

  

• Hazard Symbols:

   T:Toxic;
  

• Risk Codes:

  R25:;
  

• Safety Description:

  S45:;
  

• Company:

  Hengyang Desen Biotechnology Co., Ltd.     [ China ]        

• Contact:

  ava

• Tel:

  86-18908446905

• Fax:

• Email:

  ava@ycgmp.com