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Atorvastatin Calcium

Details for Atorvastatin Calcium

Atorvastatin Calcium

Category:

Pharmaceuticals and Biochemicals/Cardiovascular agents

Atorvastatin Calcium
CAS NO: 134523-00-5
EC NO:
Molecular Formula: C33H33CaFNO5
Molecular Weight: 582.6947
Specification: atorvastatin calcium amorphous / crystalline (api)
InChI: InChI=1/C33H34FNO5.Ca/c1-21(2)31-30(33(40)24-11-7-4-8-12-24)29(22-9-5-3-6-10-22)32(23-13-15-25(34)16-14-23)35(31)18-17-26(36)19-27(37)20-28(38)39;/h3-16,21,26-27,36-37H,17-20H2,1-2H3,(H,38,39);/q;+2/p-1/t26-,27-;/m1./s1
Packing: 10 kg/drum
Product description:
Product Name:atorvastatin calcium amorphous / crystalline Other names: Lipitor, Atorvastatin, Atorvastatin Ca, Atorvastatin calcium, Atarvadel Category: pharmaceutical raw material bulk drugs api Cas.No.: 134523-03-8 M.F.: C66H68CaF2N4O10.3H2O Qaulity Standard: YBH00062011 Edition: CP Applicable category: Antilipemic agent Finished dosage: Atorvastatin calcium tablet Appearance: white or almost white powder, odourless, tasteless, slightly hygroscopicity; Freely soluble in methanol,very slightly soluble in chloroform,not soluble in water,ethyl acetate,aether and cyclohexane; Assay: 98% - 102%,on the anhydrous basis; Loss on drying: 3%~6% Specific rotation: -9°~-7° Related impurities: total impurities ≤1%; individual impurity≤0.3%; Heavy metal: ≤ 20 PPM Packing: 10 kg/drum Advantage: High purity, Low heavy metal, Low related impurities, GMP certificate, Profession Activity & Sevice: pharmaceuticals looking for distributors, wholesale pharmaceutical generic drugs, provide lab testing service pharmaceutical Product Introduction: Atorvastatin Calcium is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2008 sales of US$12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world. U.S. patent protection was scheduled to expire in June 2011.
Uses: Antilipemic agent
Synonyms: (3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid;Atorvastatin Acid;1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-;1H-PYRROLE-1-HEPTANOIC ACID;(3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid;calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate};(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid;(3S,5S)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid;1H-pyrrole-1-heptanoate, 3-benzoyl-5-(4-fluorophenyl)-β,δ-dihydroxy-2-(1-methylethyl)-4-phenyl-, calcium salt, (betaR,deltaR)- (1:1);
Molecular Structure: Atorvastatin Calcium 134523-00-5
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