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Amiodarone hydrochloride CAS 19774-82-4 for Antiarrhythmic (jerryzhang001@chembj.com)

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  Post Date: Apr 20,2017
  Expiry Date: Apr 20,2018
  Detailed Description: Cas No. :19774-82-4 Amiodarone hydrochloride CAS 19774-82-4 for Antiarrhythmic

Product Name: Amiodarone hydrochloride;
Synonyms: 2-butyl-3-benzofuranyl4-(2-(diethylamino)ethoxy)-3,5-diiodophenylketonehyd;cordarone;ketone,2-butyl-3-benzofuranyl4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl,hyd;l3428;l3428labaz;skf33134a;trangorex;2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;

CAS: 19774-82-4;
MF: C25H29I2NO3.ClH;
EINECS: 243-293-2;
Product Categories: Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Ion transporter and other ion channel;API;

Melting point: 154-158°C;
storage temp.: 2-8°C;

Description:

Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats.[1] This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. It can be given by mouth, intravenously, or intraosseously. When used by mouth it can take a few weeks for effects to begin.

Medical uses:

Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the chronic suppression of arrhythmias. It is used both in supraventricular arrhythmias and ventricular arrhythmias.

Cardiac arrest:

Defibrillation is the treatment of choice for ventricular fibrillation (VF) and ventricular tachycardia resulting in cardiac arrest. However, amiodarone has been used in shock-refractory VF. The 2010 guidelines of the American Heart Association included amiodarone as a second line agent (after epinephrine or vasopressin). They believed that amiodarone was more effective than lidocaine in VF or pulseless ventricular tachycardia.

Ventricular tachycardia:

Amiodarone may be used in the treatment of ventricular tachycardia in certain instances. Individuals with hemodynamically unstable ventricular tachycardia should not initially receive amiodarone. These individuals should be cardioverted.

Amiodarone can be used in individuals with hemodynamically stable ventricular tachycardia. In these cases, amiodarone can be used regardless of the individual's underlying heart function and the type of ventricular tachycardia; it can be used in individuals with monomorphic ventricular tachycardia, but is contraindicated in individuals with polymorphic ventricular tachycardia as it is associated with a prolonged QT interval which will be made worse with anti-arrhythmic drugs.

Atrial fibrillation:

Individuals who have undergone open heart surgery are at an increased risk of developing atrial fibrillation (or AF) in the first few days post-procedure. In the ARCH trial, intravenous amiodarone (2 g administered over 2 d) has been shown to reduce the incidence of atrial fibrillation after open heart surgery when compared to placebo. However, clinical studies have failed to demonstrate long-term efficacy and have shown potentially fatal side effects such as pulmonary toxicities. While amiodarone is not approved for AF by the FDA, it is a commonly prescribed off-label treatment due to the lack of equally effective treatment alternatives.



  CAS Registry Number:

19774-82-4
  Synonyms: ;Amiodarone hydrochloride;Amiodarone hydrochlorde;
  Molecular Formula: C25H29I2NO3·HCl;C25H30ClI2
  Molecular Weight: 681.78
  Molecular Structure: 19774-82-4 Amiodarone HCL
  Hazard Symbols:  Xn:Harmful;
  Risk Codes: R20/21/22:;
  Safety Description: S36:;

  Company: Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        
  Contact: Jerry Zhang
  Tel: 86-25-52198306
  Fax:
  Email: jerryzhang001@chembj.com
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