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99% USP 136-47-0 Tetracaine HCl/Tetracaine Hydrochloride Tetracaine HCl

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  Post Date: Dec 10,2016
  Expiry Date: Dec 10,2017
  Detailed Description: Cas No. :136-47-0 Quantity: 5Metric Tons
Specs:USP
Price:1 USD Metric Tons
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99% USP 136-47-0 Tetracaine HCl/Tetracaine Hydrochloride
Tetracaine HCl
Alias: Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS NO.: 136-47-0
EINECS: 205-248-5
MF: C15H25ClN2O2
MW: 300.82
MS:99% USP 136-47-0 Tetracaine HCl/Tetracaine Hydrochloride

Melting point: 149°C
Assay: 99%
Grade: Pharmaceutical Grade
Storage: Closed, confined and shading preservation
Manufacturer: Simeiquan
Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

Description:

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Application:

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

COA:

Test Items Specification Test Results
Appearance Fine, white, crystalline, odorless powder confirm
Identification ABC in Pass confirm
Solubility Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene confirm
USP Reference standards USP Tetracaine Hydrochloride RS. USP Endotoxin RS. confirm
Melting point 145~150 degree 146.0~147.5 degree
Chromatographic purity In Pass confirm
Related substance Not more than the reference solution 0.05% confirm
Heavy metals ≤10ppm confirm
PH 4.5-6.5 5.8
Residue on ignition ≤0.10% 0.05%
Loss on Drying ≤ 0.5% 0.19%
Assay 98.0 -101.0% 100.1%
Conclusion Confirms USP 32

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  CAS Registry Number:

136-47-0

  Synonyms: ;Tetracaine HCl;2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride;4-(butylamino)-Benzoic acid, 2-(dimethylamino)ethyl ester, monohydrochloride;p-butylaminobenzoyl-2-dimethylaminoethanol hydrochloride;Amethocaine hydrochloride;Anethaine;Butethanol;Curtacain;Decicain;Gingicain M;Menonasal;Pantocaine;Pontocaine hydrochloride;Tonexol;Tetracaine·HCL;2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride (1:1);Tertracaine HCL;
  Molecular Formula: C15H25ClN2O2
  Molecular Weight: 300.8242
  Molecular Structure: 136-47-0 tetracaine hydrochloride
  Hazard Symbols:  T:Toxic;
  Risk Codes: R25:;
R36:;
R43:;
  Safety Description: S26:;
S36/37:;
S45:;

  Company: Wuhan Yuancheng Gongchuasng Technology Co.,Ltd     [ China ]        
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