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Dutasteride 164656-23-9

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  Post Date: Jan 15,2019
  Expiry Date: Jan 15,2020
  Detailed Description: Cas No. :164656-23-9 Dutasteride (CAS 164656-23-9)

Synonym: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Avolve; GG 745; GI 198745; Veltride
Application: A dual inhibitor of 5α-reductase isoenzymes type 1 and 2
CAS Number: 164656-23-9
Purity: ≥99%
Molecular Weight: 528.53
Molecular Formula: C27H30F6N2O2

Description
Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.
Technical Information
Appearance: Crystalline powder
Physical State: Solid
Solubility: Soluble in ethanol (44 mg/ml), methanol (64 mg/ml), polyethylene glycol 400 (3 mg/ml), and DMSO (62 mg/ml at 25 °C 117mM). Insoluble in water.
Storage: Store at 4° C
Melting Point: 247-248 °C
Boiling Point: ~620.3 °C at 760 mmHg (Predicted)
Density: ~1.3 g/cm3 (Predicted)
Refractive Index: n20D 1.52 (Predicted)
IC50: 3 β-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase: IC50 >0.15 mM (Mycobacterium tuberculosis)
pK Values: pKa: 13.32 (Predicted)
Safety and Reference Information
PubChem CID: 6918296
MDL Number: MFCD00937869
Beilstein Registry: 7401530
SMILES: C[C@]12CC[C@H]3[C@@H](CC[C@H]4NC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)NC1=CC(= CC=C1C(F)(F)F)C(F)(F)F

  CAS Registry Number:

164656-23-9
  Synonyms: ;(5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;(4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;(4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide;
  Molecular Formula: C27H30F6N2O2
  Molecular Weight: 528.5297
  Molecular Structure: 164656-23-9 Dutasteride

  Company: Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd     [ China ]          
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