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Sitagliptin Phosphate 654671-78-0

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  Post Date: Apr 21,2024
  Expiry Date: Apr 21,2025
  Detailed Description: Cas No. :654671-78-0;847445-79-8 Quantity: 500Kilograms
Specs:Assay: 98.0%~102.0%
Payment Method: L/C; T/T
Sitagliptin Phosphate
CAS 654671-78-0
Molecular Formula: C16H18F6N5O5P
Molecular Weight: 505.31
Synonyms: (2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt; MK 0431;
Package: less than 3kg, moisture-proof plastic bag inside, alu-foil bag outside; 3kg~25kg, moisture-proof plastic bag inside, carton outside.
Function: Sitagliptin is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Sitagliptin was approved by the U.S. Food and Drug Administration (FDA) on October 17, 2006, and is marketed in the US as Januvia by Merck & Co.
Items Specification
Appearance White or off white powder
Solubility Easy to dissolve in water
Identification HPLC
IR
Water ≤1.0%
Melting point 203.0℃~205.0℃
Heavy metals ≤20ppm
Residue on ignition ≤0.1%
Chiral impurities ≤1.0%
Specific rotation -18.0°~-23.0°(C=1,water)
Related impurities Total impurity≤1.0%
Assay 98.0%~102.0%
Conclusion Comply with In-house standard.

  CAS Registry Number:

654671-78-0;847445-79-8
  Synonyms: ;sitagliptin phosphate intermediates;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate;(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate;
  Molecular Formula: C16H18F6N5O5P
  Molecular Weight: 505.3088
  Molecular Structure: 654671-78-0;847445-79-8 sitagliptin phosphate

  Company: Shanghai DND Pharm-Technology Co., Inc.     [ China ]          
  Contact: Arron Yu
  Tel: 021-58783620
  Fax: 021-58783595
  Email: sales@dndpharm.com
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