Product Name:  Pemetrexed Disodium

CAS RN: 150399-23-8

Molecular Formula: C20H19N5Na2O6         Molecular Weight: 471.37

Character: white or white crystalline powder; odorless,tasteless, easily absorb water;

Solubility: freely soluble In Water,practically insoluble In chloroform, slightly soluable in Methanol;

Specific Rotation: +10°~16°;

Identification: (1)flame reaction with sodium salt;

                      (2)The reaction time in the chromatogram of the assay preparation coorresponds to that in the chromatogram of the standard preparation, as obtained in the assay;

                      (3)IR: should conform to the standard;

PH: 6.5-8.0;                                 

Clear and color of solution: should conform to standard;

Related substances: Individual impurity: ≤0.5%;

                                 tatal impurity: ≤1.0%;

Ethanol, Methylene Chloride, ethyl acetate, N,N-dimethylformamide dimethyl acetal:

Ethanol ≤ 0.5%,

Methylene Chloride≤0.06%,

ethyl acetate≤ 0.5%,

N,N-dimethylformamide dimethyl acetal≤ 0.088%;

Water: 7.2%-10.2%;

Assay:not less than 98.5%(on andydrous basid).

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