Hubei widely chemical technology Co., Ltd

Pemetrexed Disodium

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt;Premetred disodium;N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-D-glutamic acid;sodium 2-({4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate hydrate (2:1:7);

• CAS NO :

  150399-23-8

• EC NO :

• Molecular Formula :

  C₂₀H₃₃N₅Na₂O₁₃

• Molecular Weight :

  597.4813

• Main Specifications :

  98.5%

• InChI :

  InChI=1/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2

• Product description :

  Product Name:  Pemetrexed Disodium

  CAS RN: 150399-23-8

  Molecular Formula: C20H19N5Na2O6         Molecular Weight: 471.37

   

  Character: white or white crystalline powder; odorless,tasteless, easily absorb water;

  Solubility: freely soluble In Water,practically insoluble In chloroform, slightly soluable in Methanol;

  Specific Rotation: +10°~16°;

  Identification: (1)flame reaction with sodium salt;

                        (2)The reaction time in the chromatogram of the assay preparation coorresponds to that in the chromatogram of the standard preparation, as obtained in the assay;

                        (3)IR: should conform to the standard;

   

  PH: 6.5-8.0;                                 

  Clear and color of solution: should conform to standard;

  Related substances: Individual impurity: ≤0.5%;

                                   tatal impurity: ≤1.0%;

   

  Ethanol, Methylene Chloride, ethyl acetate, N,N-dimethylformamide dimethyl acetal:

  Ethanol ≤ 0.5%,

  Methylene Chloride≤0.06%,

  ethyl acetate≤ 0.5%,

  N,N-dimethylformamide dimethyl acetal≤ 0.088%;

   

  Water: 7.2%-10.2%;

  Assay:not less than 98.5%(on andydrous basid).

   

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• Molecular Structure :