Shouguang Jinyu Chemical Co., Ltd.

2-hydroxypyrazine

• Category :

  Intermediates/Pharmaceutical intermediates

• Synonyms :

  (1H)-Pyrazin-2-one;NSC 36081;pyrazin-2(1H)-one;Pyrazin-2-ol;2-Hydroxypyrazine;

• CAS NO :

  6270-63-9

• EC NO :

  228-455-2

• Molecular Formula :

  C₄H₄N₂O

• Molecular Weight :

  96.0874

• Main Specifications :

  99%

• InChI :

  InChI=1/C4H4N2O/c7-4-3-5-1-2-6-4/h1-3H,(H,6,7)

• Packing :

  1-25kg

• Product description :

  Methyl Chloroacetate with ammonia and then amination, cyclization of prepared 2- B two aldehyde hydroxyl pyrazine. The ammonia water cooling to 0 DEG, drop the chlorination of methyl acetate, insulation 2h. A through ammonia to a specified amount of 20 DEG C, standing reaction time was 8h after, eliminate more than ammonia, heating to 60 DEG C, concentrated under reduced pressure to the reaction solution with a relative density of 1.08 (50 degrees Celsius), amino acetamide hydrochloride. Reaction liquid cooled to 0 DEG C and remain below 0 DEG C in turn drops with sodium hydroxide solution with glyoxal, and Bi, reaction time is 30min, at 25 DEG C insulation 2h, vacuum concentrating, cooling crystallization, filtration, drying, 2 - hydroxyl pyrazine sodium. Yield 67%. Shandong Jinyu Chemical Group Co., Ltd. is located in beautiful vegetable Town, Shouguang, is a set of pharmaceutical grade chemicals, pesticide chemical class, leading products: pentaerythritol phosphate (PEPA), hydroxylamine hydrochloride, and, gamma - butyrolactone, aldehyde, pyrimidine, nickel hydroxide, sodium hydroxide, gluconic acid, n methyl aniline, toluene. Jin Yu technology is a leading fine chemicals custom service provider is also the gold supplier of China Pharmaceutical and chemical industry group corporation. We focus on pesticides, pharmaceuticals, and other fine chemicals, and are committed to providing integrated services throughout the life cycle of the product. We adhere to economic benefit and social responsibility is one of the development concept, as a basis for the sustainable development of the company's; by continuing to provide customized services and innovative technologies to meet current and future customer needs, customers' satisfaction. The basis of sustainable development is to maintain balance in economy, ecology and society. We firmly believe that through the comprehensive consideration of social responsibility, environmental protection, economic benefits to ensure long-term sustainable development of enterprises, the implementation of sustainable development strategy is an important factor for enterprises to maintain long-term competitive advantage. In consolidate and expand the competitive advantage in the intermediate market at the same time, the company actively implement the "transfer mode, adjust the structure of" the development of ideas, and strive to enhance the capability of independent innovation, adjust and optimize industrial structure, accelerate the characteristics of raw material medicine and bio pharmaceutical research and development, promote the industry value chain to enhance, the initial formation of the from the basic chemical raw materials and pharmaceutical intermediates, which is composed of characteristics of raw material medicine and bio pharmaceutical, a clear competitive advantage of high-tech product chain and industry group. Over the next few years, the company will to cephalosporin intermediate based, go high-tech, high output development, aim at the high-tech, high added value, high returns of pharmaceutical and chemical products and special raw material medicine, will continue to increase the intensity of technological innovation, improve enterprise capability of independent innovation, adjust and optimize the industrial structure, focus on accelerating the development of bio pharmaceutical and the characteristics of raw material medicine industry, promote the industry value chain, the company truly become the mainstream of the global pharmaceutical market leading pharmaceutical and chemical products and characteristics of pharmaceutical raw materials suppliers. SalesA: Manager Zhou Mailbox:chinalukeone@yeah.yet Sales B: Manager Hu Mailbox:chinaluketwo@yeah.yet Fax: 0536-5676556 Contact phone:0086-0536-5258520 13583692095

• Uses :

  Hydroxyl pyrazine is mainly used to synthesize sulfanilamide methoxy pyrazine SMPZ, also used in the synthesis of 2 - halogenated pyrazine and 2-cyano pyrazine, etc. drug intermediates.

• Molecular Structure :