Glibenclamide
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| Post Date: | Jan 09,2018 |
| Expiry Date: | Jul 08,2018 |
| Detailed Description: |
Cas No. :10238-21-8
Quantity: mass in stockKilograms Specs:white powder Price:negotiable USD Kilograms Payment Method: T/T, Western Union,Moneygram and Bitcoin. Description: Glibenclamide, also known as glyburide, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics. It was developed in 1966 in a cooperative study between Boehringer Mannheim (now part of Roche) and Hoechst (now part of Sanofi-Aventis). Medical uses It is used in the treatment of type 2 diabetes. As of 2003, in the United States, it was the most popular sulfonylurea. It is not as good as either metformin or insulin in those who have gestational diabetes. Side effects and contraindications This drug is a major cause of drug-induced hypoglycemia. The risk is greater than with other sulfonylureas. Cholestatic jaundice is noted. Glibenclamide may be not recommended in those with G6PD deficiency, as it may cause acute haemolysis. Mechanism of action The drug works by binding to and inhibiting the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1) in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening voltage-dependent calcium channels. This results in an increase in intracellular calcium in the beta cell and subsequent stimulation of insulin release. After a cerebral ischemic insult, the blood–brain barrier is broken and glibenclamide can reach the central nervous system. Glibenclamide has been shown to bind more efficiently to the ischemic hemisphere. Moreover, under ischemic conditions SUR1, the regulatory subunit of the KATP- and the NCCa-ATP-channels, is expressed in neurons, astrocytes, oligodendrocytes, endothelial cells and by reactive microglia. |
| CAS Registry Number: | 10238-21-8 |
| Synonyms: | ;glybenclamide;glyburide usp;Glibenclamide;Glyburide;5-chloro-n-(2-(4-((((cyclohexylamino)carbonyl)-amino)sulfonyl)phenyl)-ethyl)-2-methoxybenzamide;5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide;5-chloro-2-methoxy-N-[2-[4-(phenylcarbamoylsulfamoyl)phenyl]ethyl]benzamide;5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide; |
| Molecular Formula: | C23H22ClN3O5S |
| Molecular Weight: | 487.9559 |
| Molecular Structure: | 
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| Company: | Hengyang Desen Biotechnology Co., Ltd. [ China ] |
| Contact: | ava |
| Tel: | 86-18908446905 |
| Fax: | |
| Email: | ava@ycgmp.com |
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