AZD6482
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| Post Date: | Apr 03,2015 |
| Expiry Date: | Apr 02,2016 |
| Detailed Description: |
Cas No. :1173900-33-8
Quantity: 50g Specs:98% purity Payment Method: T/T, Western Union AZD6482 is a potent, selective and ATP competitive PI3Kβ inhibitor (IC(50) 0.01 μm). A maximal anti-platelet effect was achieved at 1 μm in the in vitro and ex vivo tests both in dog and in man. In dog, in vivo AZD6482 produced a complete anti-thrombotic effect without an increased bleeding time or blood loss. AZD6482 was well tolerated in healthy volunteers during a 3-h infusion. The ex vivo anti-platelet effect and minimal bleeding time prolongation in the dog model translated well to data obtained in healthy volunteers. AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). In the euglycemic hyperinsulinemic clamp model, in rats, glucose infusion rate was not affected at 2.3 μm but reduced by about 60% at a plasma exposure of 27 μm. In man, the homeostasis model analysis (HOMA) index increased by about 10-20% at the highest plasma concentration of 5.3 μm. |
| CAS Registry Number: | 1173900-33-8 |
| Company: | Shanghai Sun-shineChemical Technology Co.,Ltd. [ China ] |
| Contact: | Rosie |
| Tel: | +86-027-59253327 |
| Fax: | 0086-27-5925 3326 |
| Email: | sales02@sun-shinechem.com |
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