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Acotiamide

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  Post Date: Dec 07,2018
  Expiry Date: Dec 07,2019
  Detailed Description: Cas No. :185106-16-5

Pharmacokinetic data


Protein binding
84.21–85.95%


Metabolism
UGT1A8 and 1A9 (major)


Biological half-life
10.9–21.7 hours


Excretion
Feces (92.7%), urine (5.3%)[1]


Identifiers




IUPAC name[show]

N-{2-[bis(1-Methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide





CAS Number



185106-16-5 N





PubChem CID



5282338





ChemSpider



4445505 Y





UNII



D42OWK5383





KEGG



D08838 N





ChEMBL



CHEMBL2107723 N





Chemical and physical data


Formula
C21H30N4O5S


Molar mass
450.55 g/mol


3D model (Jmol)



Interactive image







SMILES[show]


O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O








InChI[show]


InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) Y


Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N Y






NY (what is this?) (verify)


Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.[2] It acts as an acetylcholinesterase inhibitor.

  CAS Registry Number:

185106-16-5
  Synonyms: ;N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide;Acotiamide;
  Molecular Formula: C21H30N4O5S
  Molecular Weight: 450.5517
  Molecular Structure: 185106-16-5 N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide

  Company: Jinan Chenghishaungda Chemical Co.,LTD     [ China ]        
  Contact: Allen
  Tel: 15689693073
  Fax: 0531-58897032
  Email: 3118607598@qq.com
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