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Baclofen

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  Post Date: Jun 04,2014
  Expiry Date: Dec 01,2014
  Detailed Description: Cas No. :1134-47-0 English name: Baclofen

Chinese alias: baclofen, Beikang Fen, shellfish can be fun, and the road trip, Lee Road line, baclofen, chlorobenzene GABA, Buck quinoxyfen (γ-aminobutyric acid analogs),

English Name: Baclon, Baclospas, Gabalin, Gabalon, Neurospas, Spastin, Spastion

Pharmacological]

This product is a skeletal muscle relaxant. Mechanism is not clear, may interfere with the excitatory neurotransmitter release, inhibition of synaptic conduction between the spinal cord.

Pharmacokinetics

Oral rapidly from the gastrointestinal tract, completely absorbed. After oral administration of 1 ~ 3h, reached a peak plasma concentration, but larger individual differences. Half-life of 3 ~ 4h. 70% to 80% of the drug excreted unchanged in the urine discharged from approximately 15% metabolized by the liver.

[Pharmacological action] Baclofen can activate GABAβ receptors, reducing spinal monosynaptic reflex potential or synaptic and post-spinal reflex potentials between the root and the root, producing skeletal muscle relaxation, since the 1970s, has been widely used abroad spasticity in spinal cord injury patients, the domestic use of these drugs has not been reported, this drug has been licensed Health Ministry pharmaceutical Affairs Division, agreed to apply this medicine clinic.

  CAS Registry Number:

1134-47-0
  Synonyms: ;(+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal;4-amino-3-(4-chlorophenyl)butyric acid;Atrofen;beta-(4-chlorophenyl)gaba;beta-(4-chlorophenyl)-gamma-aminobutyric acid;ba 34647;baclon;beta-(aminomethyl)-4-chlorobenzenepropanoic acid;beta-(aminomethyl)-p-chlorohydrocinnamic acid;c 34647ba;ciba 34,647-ba;Lioresal;gamma-amino-beta-(p-chlorophenyl)butyric acid;4-amino-3-(4-chlorophenyl)butanoic acid;(3S)-4-amino-3-(4-chlorophenyl)butanoic acid;
  Molecular Formula: C10H12ClNO2
  Molecular Weight: 213.6608
  Molecular Structure: 1134-47-0 Baclofen
  Hazard Symbols:  T:Toxic;
  Risk Codes: R61:;
R25:;
R36/37/38:;
R42/43:;
  Safety Description: S52:;
S22:;
S36/37/39:;
S45:;

  Company: Hubei Pharmaceutical Co., Ltd. Shi Nan ninety-five     [ China ]        
  Contact: kevin peng
  Tel: +86-027-13554447107
  Fax:
  Email: 13554447107@163.com
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