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ChlorMadinone acetate

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  Post Date: Jul 09,2015
  Expiry Date: Jul 08,2016
  Detailed Description: Cas No. :302-22-7 Quantity: 3000Kilograms
Specs:96%
Payment Method: Western Union/MoneyGram/T,T
ChlorMadinone acetate

Synonyms:17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione;17-Acetoxy-6-chloro-6-dehydroprogesterone;17-alpha-Acetoxy-6-chloro-6,7-dehydroprogesterone;17-alpha-acetoxy-6-chloro-6-dehydroprogesterone;17alpha-Acetoxy-6-chloro-6-dehydroprogesterone;17-alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione;17alpha-Acetoxy-6-chloropregna-4,6-diene-3,20-dione;20-dione,17-(acetoxy)-6-chloro-pregna-6-diene-3

CAS:302-22-7
EINECS:206-118-0
Purity:>96%
Apperance: white or off-white crystalline powder
Molecular Weight:404.93
Molecular formula:C23H29ClO4
Molecular Weight:404.93
Chemical structure:

Indications: potent oral estrogen and progestin did not have its anti-androgenic activity ovulation with 18.4 times for the norethindrone long-term estrogen quinestrol compatibility compound composed quinestrol piece can be used as a long-term oral contraceptive drug medication 1 to 25, such as increased contraceptive norethindrone form a new "triple quinestrol film" clinical better. chlormadinone composite progesterone after pill. Pharmacological effects of the anti-pregnancy film with ether (pill) the same, mainly to increase the consistency of cervical mucus and suppress endometrial development, the impact speed of the fertilized egg

detail
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus. Pharmacokinetic studies have shown rapid and almost complete absorption after oral administration, and CMA is being bound to albumin rather than SHBG (Sex-Hormone-Binding-Globulin). Multiple dosing studies have demonstrated that steady state is reached by day 7 after oral administration with peak plasma concentrations in the region of 2 ng/ml. After a single dose of CMA the half-life time is around 34 hours and after multiple dose administration approximately 38 hours. Safety studies have indicated that CMA has no clinically relevant effect on a wide range of metabolic parameters in normal subjects. Further studies in groups at high thromboembolic risk have shown that CMA alone produces a relative risk of 0.8 which is not considered significant. These results indicated the potential for CMA to be combined with ethinylestradiol in an oral contraceptive which provides highly effective contraception and excellent cycle control.

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  CAS Registry Number:

302-22-7

  Synonyms: ;17-Acetoxy-6-Chloro-6-Dehydroprogesterone;6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate;(8Xi,9Xi,14Xi)-6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate;
  Molecular Formula: C23H29ClO4
  Molecular Weight: 404.927
  Molecular Structure: 302-22-7 chlormadinone acetate
  Hazard Symbols:  T:Toxic;
  Risk Codes: R60:;
R61:;
R40:;
R48:;
  Safety Description: S53:;
S22:;
S36/37/39:;
S45:;

  Company: Hubei Saichuang Technology Co., Ltd.     [ China ]        
  Contact: sherry ren
  Tel: 18188938005
  Fax: 027-88048077-886
  Email: ycgsales02@yccreate.com
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