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Epitalon

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  Post Date: Sep 21,2016
  Expiry Date: Sep 21,2017
  Detailed Description: Cas No. :307297-39-8 Quantity: 1Kilograms
Specs:alisa@pharm-china.com
Price:1 USD Kilograms
Payment Method: Western Union, MoneyGram, Bank transfer, Bite
Epitalon

1. Quick Details:
Telomeres act as a biological clock governing the life of cells. Telomeres shorten progressively with each cell division until the cell can no longer divide and dies.

When the telomere becomes too short, it no longer plays a protective role. The cell will interpret this as a corruption of its DNA, enter senescence and stop its growth. Organs deteriorate even more than their constituent cells die or come into senescence.

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a. Fast Delivery: 3 work days after received payment.
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Raw Powder
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4. More Information About Epitalon:

Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. This pineal peptide preparation is secreted in the epithlamium-epiphyseal region of the brain. Its more prominent tasks are: to regulate metabolism in the epiphysis, increase the sensitivity of hypothalamus to its natural hormonal influences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body. Epithalamin increases a person's resistance to emotional stress and also acts as an antioxidant.

Epithalamin was first discovered in the late 1980's by Prof. Vladimir Khavinson from St. Petersburg, Russia. It has been studied extensively ever since. It is known by several names, including Epitalon, Epithalon, Epithalone, Epithalamin and Epithalamine. Since all the patents are held by the Russian inventor there is not much interest for this tetra-peptide from the western big pharma industry. This makes the substance fairly unknown in the west due to the absence of marketing usually seen with big pharma products. In Russia it is currently in clinical studies and shows prospective results as treatment for liver disorders, neuropathology, psychiatry and geriatrics.

Epitalon is one of the very few substances which are able to activate Telomerase (telomere terminal transferase) enzyme in humans. Telomerase renews (elongates) the telomeres, which are responsible for protection of the human DNA from damage and cancer causing errors.

Treatment of aging cells in culture with Epithalon induced elongation of telomeres to the size comparable to their length during the early cell divisions. Epitalon treated cells with elongated telomeres made 10 extra divisions (44 passages) in comparison with the control and continued dividing. Thus, Epithalon prolonged the vital cycle of normal human cells due to overcoming the Heyflick cell division limit. (reference: V. Khavinson et all. in Bulletin of Experimental Biology and Medicine. June 2003, PMID: 12937682)

From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline. There were 54 mice in each group. The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. However, it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05). It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01) and by 12.3% the maximum life span in comparison with the control group. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice.

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6. Seller's Information:

Company: Shanghai Yijing Pharmaceutical Co., Ltd
Mob: +OO86-13O26163653

7. How to place an order:

Send me an email at the address above, tell me product name and quantity.

  CAS Registry Number:

307297-39-8

  Synonyms: Epithalon;Epitalon;L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine;
  Molecular Formula: C14H22N4O9
  Molecular Weight: 390.3459
  Molecular Structure: 307297-39-8 L-Alanyl-L-glutamyl-L-aspartyl-glycine

  Company: Shanghai Yijing Pharmaceutical Co., Ltd     [ China ]        
  Contact: Alisa
  Tel: +86-130-26163653
  Fax:
  Email: alisa@pharm-china.com
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