Exemestane
Inquiry
| Post Date: | Jan 07,2014 |
| Expiry Date: | Jan 07,2015 |
| Detailed Description: |
Cas No. :107868-30-4
Quantity: 100Kilograms Specs:Corporate standards Payment Method: According to customer requirements Exemestane Chemical name 1,4- diene -3,17- two keto -6- methylene androstane or 6- methylene androst -1, 4- diene -3, 17- two ketone CAS number: 107868-30-4[1] Molecular structure The molecular formula C20H24O2 The molecular weight of 296.40 The physical and chemical properties Density: 1.13g/cm3 Melting point: 155.13℃ Boiling point: 453.7°C at 760 mmHg Flash point: 169°C Steam pressure: 2.02E-08mmHg at 25°C Content: 99% Packing: 1kg/ aluminum bag The growth of breast cancer cells may be dependent on the presence of estrogen, estrogen cycle in women after menopause (estrone and estradiol) will be the main adrenal and ovary of androgen by peripheral tissue aromatase (androstene two ketones and testosterone) and. Through the inhibition of aromatase to stop estrogen production is an effective method for the selective treatment of postmenopausal hormone dependent breast cancer. Exemestane is an irreversible steroidal aromatase inactivator, structure and the natural substrate androstene two ketone similarity, as pseudo substrate of aromatase, by irreversibly bind to the active site of the enzyme and its inactivation (also known as "the role of self-destructive repression"), from the decreased estrogen levels in postmenopausal women in blood circulation, but does not significantly affect the biosynthesis of corticosteroids and aldosterone in the adrenal gland. In the more than 600 times the concentration of aromatase inhibition effect on steroidogenesis, other enzymes in the pathway is not affected. |
| CAS Registry Number: | 107868-30-4 |
| Synonyms: | ;Exemestan;6-Methylenandrosta-1,4-diene-3,17-dione;10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-;6-methylideneandrosta-1,4-diene-3,17-dione;(8ξ,9ξ,14ξ)-6-methylideneandrosta-1,4-diene-3,17-dione;Exemestane(Aromasin);Exemestone; |
| Molecular Formula: | C20H24O2 |
| Molecular Weight: | 296.4034 |
| Molecular Structure: | 
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| Company: | Hubei DaTong Biological Chemical Technology Co., Ltd [ China ] |
| Contact: | Johnny |
| Tel: | 027-87666701 |
| Fax: | 027-87666700 |
| Email: | johnny@hbdatong.com |
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