Home > Offer to Sell > Pharmaceuticals and Biochemicals > Auxiliaries and miscellaneous medicinal chemicals > Legit Steroids Supplier Female Steroids Chlormadinone Acetate / CMA for Emergency Contraception CAS 302-22-7
Legit Steroids Supplier Female Steroids Chlormadinone Acetate / CMA for Emergency Contraception CAS 302-22-7
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| Post Date: | Nov 14,2017 |
| Expiry Date: | Nov 14,2018 |
| Detailed Description: |
Cas No. :302-22-7
Quantity: 1000Kilograms Specs:10g foil bags Price:1 USD Kilograms Payment Method: Western union, money gram, t/t, btc Legit Steroids Supplier Female Steroids Chlormadinone Acetate / CMA for Emergency Contraception CAS 302-22-7 Quick Detail: Product Name Chlormadinone Acetate Chlormadinone Acetate CAS 302-22-7 Molecular Formula C23H29ClO4 Molecular Weight 404.93 EINECS 206-118-0 Appearence white crystalline powder Usage Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal) Description: Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans. The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect. Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years. The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions. Application: Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus. COA: TEST ITEMS SPECIFICATION RESULTS Description White or Almost White Crystalline Powder white powder Identification A.B. Positive Assay 97.0~102.0% 99.3% Specific Rotation +101°~+105° +102.6° Loss On Drying 1.0%max 0.27% Melting Point 153~157°C 153.0~155.0°C Organic Volatile Impurities meets the requirement. Conforms Related Substances meets the requirement. Conforms Residual Solvents meets the requirement. Conforms Particle Size 100% ≤ 20 microns Conforms Conclusion The specification conform with USP30 standard Usage: Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus. The guidance： Payment Western union , Money gram, T/T and Bitcoin Shipping DHL, TNT, FedEx, HKEMS, EMS, UPS, EUB etc Packaging Discreet Package Delivery Arranged within 12 hours upon receipt of payment Minimum Order 10ml Discount 1.Multiple items ordered per time 2.Large quantity of each item |
| CAS Registry Number: | 302-22-7 |
| Synonyms: | ;17-Acetoxy-6-Chloro-6-Dehydroprogesterone;6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate;(8Xi,9Xi,14Xi)-6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate; |
| Molecular Formula: | C23H29ClO4 |
| Molecular Weight: | 404.927 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; |
| Risk Codes: | R60:; R61:; R40:; R48:; |
| Safety Description: | S53:; S22:; S36/37/39:; S45:; |
| Company: | Hengyang Desen Biotechnology Co., Ltd. [ China ] |
| Contact: | Koala |
| Tel: | +86-073-48164621 |
| Fax: | |
| Email: | koala@desen-nutrition.com |
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