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Myostatin

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  Post Date: Sep 21,2016
  Expiry Date: Sep 21,2017
  Detailed Description: Cas No. :00-00-0 Quantity: 1Kilograms
Specs:alisa@pharm-china.com
Price:1 USD Kilograms
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Myostatin

1. Quick Details:
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene.[4] Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

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Raw Powder
1 Testosterone enanthate CAS: 315-37-7
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17 Boldenone Undecylenate (Equipoise) CAS: 13103-34-9
18 Boldenone Acetate CAS :2363-59-9
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4. More Information About Myostatin:
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene.[4] Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.[5][6]

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.[7]

After that discovery, several laboratories cloned and established the nucleotide sequence of a myostatin gene in two breeds of cattle, Belgian Blue and Piedmontese. They found mutations in the myostatin gene (various mutations in each breed) which in one way or another lead to absence of functional myostatin.[8][9][14] Unlike mice with a damaged myostatin gene, in these cattle breeds the muscle cells multiply rather than enlarge. People describe these cattle breeds as "double muscled", but the total increase in all muscles is no more than 40%.[9][15][16]

Animals lacking myostatin or animals treated with substances such as follistatin that block the binding of myostatin to its receptor have significantly larger muscles. Thus, reduction of myostatin could potentially benefit the livestock industry, with even a 20 percent reduction in myostatin levels potentially having a large effect on the development of muscles.[17]

However, the animal breeds developed as homozygous for myostatin deficiency have reproduction issues due to their unusually heavy and bulky offspring, and require special care and a more expensive diet to achieve a superior yield. This negatively affects economics of myostatin-deficient breeds to the point where they do not usually offer an obvious advantage. While hypertrophic meat (e.g. from Piedmontese beef) has a place on the market due to its unusual properties, at least for purebred myostatin-deficient strains the expenses and (especially in cattle) necessity of veterinary supervision place them at a disadvantage in the bulk market.[18]

Myostatin is expressed at very low levels in cardiac myocytes.[19][20] Although its presence has been noted in cardiomyocytes of both fetal and adult mice,[21] its physiological function remains uncertain.[20] However, it has been suggested that fetal cardiac myostatin may play a role in early heart development.[21]

Myostatin is produced as promyostatin, a precursor protein kept inactive by the latent TGF-β binding protein 3 (LTBP3).[19] Pathological cardiac stress promotes N-terminal cleavage by furin convertase to create a biologically active C-terminal fragment. The mature myostatin is then segregated from the latent complex via proteolytic cleavage by BMP-1 and tolloid metallopreoteinases.[19] Free myostatin is able to bind its receptor, ActRIIB, and increase SMAD2/3 phosphorylation.[19] The latter produces a heteromeric complex with SMAD4, inducing myostatin translocation into the cardiomyocyte nucleus to modulate transcription factor activity.[22] Manipulating the muscle creatinine kinase promoter can modulate myostatin expression, although it has only been observed in male mice thus far.

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6. Seller's Information:

Company: Shanghai Yijing Pharmaceutical Co., Ltd
Mob: +OO86-13O26163653

7. How to place an order:

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  CAS Registry Number:

00-00-0


  Company: Shanghai Yijing Pharmaceutical Co., Ltd     [ China ]        
  Contact: Alisa
  Tel: +86-130-26163653
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  Email: alisa@pharm-china.com
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