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Pharmaceutical Raw Powder Pirfenidone 53179-13-8 Factory Supply Anti-Fibrosis Piresupa
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| Post Date: | Nov 20,2017 |
| Expiry Date: | Nov 20,2018 |
| Detailed Description: |
Cas No. :53179-13-8
Quantity: 1000 Specs:foil bag Price:1 USD Kilograms Payment Method: Western Union, money gram, t/t, bitcoin Pharmaceutical Raw Powder Pirfenidone 53179-13-8 Factory Supply Anti-Fibrosis Piresupa What is pirfenidone? Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen. The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease. Pirfenidone may also be used for purposes not listed in this medication guide. Basic Info: Name Pirfenidone CAS 53179-13-8 MF C12H11NO MW 185.22 Purity 99%min Appearance Off-White Solid Usage Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver Synonyms 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone Categories Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Inhibitors Description: Pirfenidone (PFD) is a novel kind of pyridine ketones which has a broad-spectrum anti-fibrotic effect, being able to prevent and reverse the formation of fibrosis and scar. It entered into market in Shionogi, Japan in 2008 and has been approved by the US food and Drug Administration. It is the first drug which has gone through phase III clinical trials (including repeating, randomized, and placebo-control) which has demonstrates its effectiveness in treating idiopathic pulmonary fibrosis (IPF); Moreover, the drug has relative good efficacy in treating some fibrotic diseases such as renal interstitial fibrosis and liver fibrosis. Furthermore, it is also widely applied in the phase II clinical study in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I neurofibromatosis, youth I type of neurofibromatosis and plexiform neurofibromas, diabetes together with kidney disease. Application: In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity. Quality specification: Items Specifications Results Appearance White or almost white crystalline powder Meets the requirements Identification Meets the requirements Meets the requirements Melting point 106ºC-108ºC 107.3ºC-108ºC Water (K.F) Not more than 0.5% 0.09% 2-hydroxy-5-picoline Not more than 0.15% None Any other unspecified Not more than 0.1% 0.03% Total impurity Not more than 0.5% 0.05% Bromobenzene Not more than 0.036% 0.01% Ethyl acetate Not more than 0.5% None Heavy metal Not more than 20ppm Less than 20ppm R0l Not more than 0.1% Less than 0.1% Assay Not less than 98.0% 99.5% Conclusion Comply with the requirements. How should I take pirfenidone? (1)Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pirfenidone. (2)Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. (3)Pirfenidone should be taken with food to help decrease nausea or dizziness. (4)Pirfenidone is usually taken 3 times per day. Your dose needs will change over the first 15 days of your treatment. For the first week, you will take only 1 capsule at a time. During the second week, you will take 2 capsules at a time. From the third week on, you will take 3 capsules at a time. You must follow this 2-week "dose escalation" schedule when you start taking pirfenidone, or if you start taking the medicine again after not taking it for 14 days or longer. Follow your doctor's dosing instructions very carefully. Order Process and Tips : Make an order Please make clear what product and what quantity you need Mini Order 10g Quote Prices and Specifications details(COA) would be offered for you to consider and confirm. Payment ways T/T, Western Union, Money Gram and Bitcoin Delivery ways All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) Shipping address Provide your Valid and Correct destination address info(if possible with post code, phone number). Packing Select best ways according to quantity and safety degree(Super discreet, professional and experienced) Lead time Within 12 hours upon receipt of payment Package pictures Photos of parcel would be offered to tell apart the items Tracking number Offered once it is released Shipping time About 5 working days (Door-to-Door) After-sale service 24/7 Online for any problems |
| CAS Registry Number: | 53179-13-8 |
| Synonyms: | ;5-Methyl-1-phenyl-2-(1H)-pyridone;5-methyl-1-phenylpyridin-2(1H)-one; |
| Molecular Formula: | C12H11NO |
| Molecular Weight: | 185.2218 |
| Molecular Structure: | 
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| Hazard Symbols: |  Xn:Harmful; |
| Risk Codes: | R22:; |
| Safety Description: | S36:; |
| Company: | Hengyang Desen Biotechnology Co., Ltd. [ China ] |
| Contact: | Koala |
| Tel: | +86-073-48164621 |
| Fax: | 027-88608190-722 |
| Email: | koala@desen-nutrition.com |
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