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Thymosin 1 Acetate

Inquiry
  Post Date: Oct 09,2016
  Expiry Date: Apr 07,2017
  Detailed Description: Cas No. :62304-98-7 Quantity: 1Kilograms
Price:1 USD Kilograms
Payment Method: T/T
Product Name Thymosin α1 Acetate
Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-
Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-
Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Cas No. 62304-98-7
Molecular Formula C129H215N33O55
Molecular Weight 3108.3
Purity (HPLC) 98.0%min.
Appearance? White powder
Single Impurity (HPLC)? 1.0%max
Amino Acid Composition? ±10% of theoretical
Peptide Content (N%) ?≥80.0%
Water Content(Karl Fischer)? ≤5.0%
Specific Rotation (20/D) -95.0~-105.0°(c=0.5 1%HAc)
Acetate Content (HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance? 95.0~105.0%




Description:

Thymosin Alpha-1 is a component of Thymosin Fraction 5 responsible for restoring immune function in animals lacking thymus glands. It was the original peptide synthesized from the Thymosin Fraction 5. Unlike β Thymosins, which are genetically and chemically unrelated, Thymosin α 1 is produced as a 28-amino acid peptide fragment from a longer, 113-amino acid precursor, prothymosin alpha. Research has shown it to enhance cell-mediated immunity in experimental animals and research subjects...
Thymosin Alpha-1 is being researched for the treatment of Hepatitis B and C, and it is also approved for inclusion with vaccines to boost the immune response in the treatment of other diseases.
Exhibiting a variety of immune regulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.

Application:

Thymosin α 1 is now approved in 35 under developed or developing countries for the treatment of Hepatitis B and C, and it is also used to boost the immune response in the treatment of other diseases.

  CAS Registry Number:

62304-98-7

  Synonyms: ;Thymotin;Thymalfasin;N-Acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-L-asparagine;Thymosin alpha1 (human);Thymosin alpha1 (ox);UNII-W0B22ISQ1C;Zadaxin;L-Asparagine, N-acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-asparatyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-;Thymosin alpha1 (cattle);Thymosinalpha1;Thymosin alpha 1;Thymosin α1;
  Molecular Formula: C129H215N33O55
  Molecular Weight: 3108.27549999998
  Molecular Structure: 62304-98-7 thymosin A1 bovine

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