Home > Offer to Sell > Organic chemicals and Derivatives > Acid, ester and anhydride compounds > Vecuronium bromide
Vecuronium bromide
Inquiry
| Post Date: | Jun 06,2020 |
| Expiry Date: | Jun 06,2021 |
| Detailed Description: |
Cas No. :50700-72-6
Quantity: 1Metric Tons Specs:99%min Vecuronium bromide Basic information Description References Product Name: Vecuronium bromide Synonyms: norcuron;VECURONIUM BROMIDE;VECRONIUM BROMIDE;(+)-1-(3,17-diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide;VECURONIUM BROMIDE, USP STANDARD;VECURONIUM BROMIDE, RELATED COMPOUND A3ALPHA, 17BETA-DIACETYL-OXY-2BETA, 16BETA-BISPIPERIDINYL-5ALPHA-ANDROSTAN USP STANDARD;VECURONIUM BROMIDE, EP;VECUROMIUM BROMIDE CAS: 50700-72-6 MF: C34H57BrN2O4 MW: 637.73138 EINECS: 256-723-9 Product Categories: Pharmaceutical material and intermeidates;Organics;Neuromuscular blocking agent;Steroids;Acetylcholine receptor;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;CAMPRAL Mol File: 50700-72-6.mol Vecuronium bromide Chemical Properties Melting point 227-229°C alpha +30.5～+35.0゜(D/20℃)(c=0.5,dil.HCl) storage temp. -20°C Freezer solubility Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol. form neat Merck 14,9941 BRN 4837308 InChIKey VEPSYABRBFXYIB-PWXDFCLTSA-M CAS DataBase Reference 50700-72-6(CAS DataBase Reference) Safety Information Hazard Codes Xi,Xn Risk Statements 36/37/38-22 Safety Statements 26-37/39 WGK Germany 3 RTECS TN4875000 HS Code 2933399090 Toxicity LD50 in mice: 0.061 mg/kg i.v. (Buckett) Vecuronium bromide Usage And Synthesis Description Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation. References https://en.wikipedia.org/wiki/Vecuronium_bromide https://www.drugbank.ca/drugs/DB01339 Chemical Properties White Solid Uses alcohol antagonist Uses An aminosteroid, competitive neuromuscular blocker agent. Definition ChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents. Brand name Norcuron (Organon). Biological Functions Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion. General Description Vecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0. Clinical Use Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced. Veterinary Drugs and Treatments Vecuronium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and to facilitate endotracheal intubation. It causes very minimal cardiac effects and generally does not cause the release of histamine. |
| CAS Registry Number: | 50700-72-6 |
| Synonyms: | ;Norcuron;(+)-1-(3,17-Diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide;(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane;(3alpha,5alpha)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide;(2beta,3alpha,8xi,9xi,14xi,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide; |
| Molecular Formula: | C34H57BrN2O4 |
| Molecular Weight: | 637.7314 |
| Molecular Structure: | 
|
| Company: | shanghai missyou chemical co.,ltd. |
| Contact: | eileen zhang |
| Tel: | +86-18101936766 |
| Fax: | 021-58583907 |
| Email: | eileen@shmychem.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
